Protein Variants | Comment | Organism |
---|---|---|
up | hypoxia inducible factor-2, HIF-2, preferential activation of PTPRZ1 by HIF-2, involving ELK1, an E26 transformation-specific factor that can bind to HIF-2alpha but not HIF-1alpha. A deletion mutation of one of the two Ets binding motifs located near the principal hypoxia response element similarly decreases activation of the PTPRZ1 promoter by HIF-2. IFand Ets both bind to motifs on the PTPRZ1 promoter and cooperate inpreferential upregulation of PTPRZ1, binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | PTPRZ1 is overexpressed in a number of tumors | Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
HEP-3B cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | - |
Homo sapiens |
PTPRZ1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PTPRZ1 is implicated in glioblastoma pathogenesis | Homo sapiens |