Literature summary for 3.1.3.48 extracted from

Nakashima, S.; Arnold, S.A.; Mahoney, E.T.; Sithu, S.D.; Zhang, Y.P.; D'Souza, S.E.; Shields, C.B.; Hagg, T.
Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats (2008), J. Neurosci., 28, 7293-7303.

Search for more literature for 3.1.3.48

Inhibitors

Inhibitors	Comment	Organism	Structure
potassium bisperoxo(1,10-phenanthroline)oxovanadate(V)	i.e. [bpV(phen)], the peroxovanadium compound is a stable, potent and selective protein tyrosine phosphatase inhibitor. It protects dorsal column sensory axons and white matter and rescues sensory-evoked potentials in vivo after treatement with PTP or spinal cord injury, overview	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	adult female Sprague Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Rattus norvegicus	-
spinal cord	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
protein tyrosine phosphatase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	protein tyrosine phosphatases inactivate neurotrophic factor receptors and downstream intracellular signaling molecules causing neurodegeneration and loss of sensoric functions, overview	Rattus norvegicus
additional information	small-molecule protein tyrosine phosphatase inhibition is a neuroprotective treatment after spinal cord injury in adult rats	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)