Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Liu, S.; Zhou, B.; Yang, H.; He, Y.; Jiang, Z.X.; Kumar, S.; Wu, L.; Zhang, Z.Y.
    Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases (2008), J. Am. Chem. Soc., 130, 8251-8260.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Yersinia sp.

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with phenyl vinyl sulfonate or phenyl vinyl sulfone, hanging drop vapour diffusion method, using 25% (w/v) PEG3350, 100 mM NaCl, and 100 mM HEPES buffer (pH 7.0-8.0) Yersinia sp.

Inhibitors

Inhibitors Comment Organism Structure
phenyl vinyl sulfonate phenyl vinyl sulfonate-mediated PTP inactivation is active site-directed and irreversible Yersinia sp.
phenyl vinyl sulfone phenyl vinyl sulfone-mediated PTP inactivation is active site-directed and irreversible Yersinia sp.

Organism

Organism UniProt Comment Textmining
Yersinia sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Yersinia sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Yersinia sp. 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Yersinia sp.
PTP
-
Yersinia sp.
YopH
-
Yersinia sp.