Cloned (Comment) | Organism |
---|---|
expressed in U-937 cells | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of PTP-PEST by RNAi reduces formation of podosomal structures at the cell periphery and reduces bone resorption indicating a positive functional role for this PTP in promoting osteoclast activity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
- |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | PTP-PEST most likely also participates in regulating osteoclast differentiation and adhesion to bone matrix | ? | - |
? | |
additional information | Mus musculus | SHP-1 is a negative regulator of osteoclastogenic signalling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Oryctolagus cuniculus | - |
hematopoietic cell | - |
Mus musculus | - |
hematopoietic cell | - |
Oryctolagus cuniculus | - |
kidney | - |
Oryctolagus cuniculus | - |
osteoclast | - |
Mus musculus | - |
osteoclast | cyt-PTPepsilon is expressed strongly in osteoclasts and is virtually absent from osteoblasts, RPTPepsilon is not expressed in either cell type, function of cyt-PTPepsilon is critical for proper organization of podosomes in osteoclasts | Mus musculus | - |
osteoclast | PTP-oc is expressed quite strongly in osteoclasts and positively regulates osteoclast production and activity | Oryctolagus cuniculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PTP-PEST most likely also participates in regulating osteoclast differentiation and adhesion to bone matrix | Mus musculus | ? | - |
? | |
additional information | SHP-1 is a negative regulator of osteoclastogenic signalling | Mus musculus | ? | - |
? | |
phosphorylated c-Src + H2O | dephosphorylation activates c-Src | Mus musculus | c-Src + phosphate | - |
? | |
phosphorylated c-Src + H2O | dephosphorylation occurs at Tyr-527 | Oryctolagus cuniculus | c-Src + phosphate | - |
? | |
phosphorylated proline serine threonine-rich phosphatase interacting protein + H2O | - |
Mus musculus | proline serine threonine-rich phosphatase interacting protein + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cryp-2 | - |
Oryctolagus cuniculus |
cyt-PTPepsilon | non-receptor-type isoform of PTPepsilon | Mus musculus |
GLEPP-1 | - |
Oryctolagus cuniculus |
p65 PTPepsilon | - |
Mus musculus |
p67 PTPepsilon | - |
Mus musculus |
protein tyrosine phosphatase | - |
Mus musculus |
protein tyrosine phosphatase | - |
Oryctolagus cuniculus |
PTP | - |
Mus musculus |
PTP | - |
Oryctolagus cuniculus |
PTP-F | - |
Oryctolagus cuniculus |
PTP-oc | the protein is produced from the distal promotor, PTP-oc is identical to PTPRO, except that its extracellular domain is extremely short with eight amino acids in all | Oryctolagus cuniculus |
PTP-PEST | a non-receptor protein tyrosine phosphatase | Mus musculus |
PTP-U2 | - |
Oryctolagus cuniculus |
PTPepsilon | belongs to the receptor-type branch of the PTP family | Mus musculus |
PTPepsilonC | non-receptor-type isoform of PTPepsilon | Mus musculus |
PTPepsilonM | receptor-type isoform of PTPepsilon | Mus musculus |
PTPRO | a receptor-type PTP, the protein is produced from the distal promotor | Oryctolagus cuniculus |
PTPRO, truncated | the protein is produced from the proximal promotor | Oryctolagus cuniculus |
PTPRO-FL | - |
Oryctolagus cuniculus |
PTPROt | the protein is produced from the proximal promotor | Oryctolagus cuniculus |
RPTP-BK | - |
Oryctolagus cuniculus |
RPTPepsilon | receptor-type isoform of PTPepsilon | Mus musculus |
SHP-1 | - |
Mus musculus |
Src homology 2 domain-containing phosphatase-1 | - |
Mus musculus |