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Literature summary for 3.1.3.48 extracted from

  • Peters, G.H.; Iversen, L.F.; Andersen, H.S.; Moller, N.P.; Olsen, O.H.
    Residue 259 in protein-tyrosine phosphatase PTP1B and PTPalpha determines the flexibility of glutamine 262 (2004), Biochemistry, 43, 8418-8428.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular dynamics simulations of the crystal structure of the enzyme catalytic domain and of mutant R47V/D48N/M258C/G259Q, both in complex with substrate 4-nitrophenyl phosphate and as cysteine-phosphor complex Homo sapiens

Protein Variants

Protein Variants Comment Organism
R47V/D48N/M258C/G259Q molecular dynamics simulations of the crystal structure, in comparison to wild-type, movement of Q262 is restricted Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P18031
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