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Literature summary for 3.1.3.48 extracted from
- Dynamics of protein-tyrosine phosphatases in rat adipocytes (2000), J. Biol. Chem., 275, 6308-6312.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PTPalpha and PTP1B responsible for counteraction of insulin signaling, LAR and PTPalpha may act upon cell surface insulin receptors | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | PTP1B, IRS-1, SHPT2/Syp | Rattus norvegicus | 5829 | - |
| microsome | PTP1B, IRS-1, light microsomes | Rattus norvegicus | - |
- |
| additional information | detailed study on subcellular distribution of isozymes | Rattus norvegicus | - |
- |
| plasma membrane | isozymes PTPalpha, LAR | Rattus norvegicus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors | Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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