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Literature summary for 3.1.3.4 extracted from

  • Brindley, D.N.; Pilquil, C.
    Lipid phosphate phosphatases and signaling (2009), J. Lipid Res., 50 Suppl, S225-S230.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-
Homo sapiens
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-
-
Mus musculus
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-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell
-
 Homo sapiens
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embryo
-
 Drosophila melanogaster
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embryo
-
 Mus musculus
-
fibroblast
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 Rattus norvegicus
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germ cell
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 Drosophila melanogaster
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lung endothelial cell Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
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 Drosophila melanogaster
lipid phosphate phosphatase-1
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 Mus musculus
lipid phosphate phosphatase-1
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 Homo sapiens
lipid phosphate phosphatase-2
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 Mus musculus
lipid phosphate phosphatase-2
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 Rattus norvegicus
lipid phosphate phosphatase-3
-
 Mus musculus
lipid phosphate phosphatase-3
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 Homo sapiens
lipid phosphate phosphatase-3
-
 Rattus norvegicus
LPP
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 Drosophila melanogaster
LPP1
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 Mus musculus
LPP1
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 Homo sapiens
LPP2
-
 Mus musculus
LPP2
-
 Rattus norvegicus
LPP3
-
 Mus musculus
LPP3
-
 Homo sapiens
LPP3
-
 Rattus norvegicus
wun
-
 Drosophila melanogaster
wun2
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 Drosophila melanogaster
Wunen
-
 Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster Wunens are normally expressed in somatic tissues that germ cells avoid up

General Information

General Information Comment Organism
malfunction in mutants where both Wun and wun2 are disrupted, germ cells scatter throughout the embryo and eventually die Drosophila melanogaster
malfunction LPP1 hypomorph mice (Ppap2atr/tr) have depleted LPP1 expression in most tissues. Lysophosphatidate concentrations in the plasma are higher in Ppap2atr/tr mice compared with controls. Embryos from LPP3 knockout mice fail to form a chorio-allantoic placenta and yolk sac vasculature and some embryos show shortening of the anterior-posterior axis similar to axin deficiency, a critical regulator of Wnt signaling. LPP2 knockout mice are fertile and viable with no obvious phenotype Mus musculus
physiological function decreases the growth, survival, and tumorigenesis of ovarian cancer cells. LPP3 contains an exposed arginine-glycine-aspartate (RGD) cell adhesion sequence. LPP3 expression increases cell/cell interactions through alphavbeta3 and anti-alpha5beta1 integrins. LPP1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells Homo sapiens
physiological function dimerization of LPP is not required for biological activity. Wun and wun2 act redundantly in germ cells as repellant factors that guide migrating germ cells in embryos. Overexpression of wun or wun2 in somatic tissues causes germ cell repulsion and death Drosophila melanogaster
physiological function LPP3 contains arginine-glycine-glutamate (RGE) cell adhesion sequence, but murine LPP3 also interacts with alpha5beta1 and alphavalpha3 integrins. Transgenic mice that overexpress LPP1 demonstrate no significant differences in circulating lysophosphatidate concentrations compared with control mice. LPP3 functions as a Wnt signaling antagonist. Mice that overexpress LPP1 have decreased birth weight, sparse curly hair, and defective spermatogenesis causing infertility. LPP1 controls lysophosphatidate removal from the blood, which increases circulating lysophosphatidate levels. LPP2 regulates the timing of S-phase entry, but it is not essential for cell cycle progression Mus musculus
physiological function LPP3 contains arginine-glycine-glutamate (RGE) cell adhesion sequence. LPP2 activity regulates S-phase entry of the cell cycle in rat2 fibroblasts Rattus norvegicus