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Literature summary for 3.1.3.4 extracted from
- Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans (2009), J. Cell Sci., 122, 1963-1969.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q9XXT5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Caenorhabditis elegans | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipin-1 | - |
Caenorhabditis elegans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Caenorhabditis elegans | RNAi downregulation of lpin-1 | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | RNAi downregulation of lpin-1 for 48 hours or longer results in 100% embryonic lethality on N2 worms. Inactivation of lpin-1 promotes bi-nucleation. Co-depletion of lpin-1 and lamin significantly rescues the effect of lpin-1 depletion on nuclear envelope breakdown | Caenorhabditis elegans |
| physiological function | lpin-1 affects dynamics of the peripheral endoplasmic reticulum. The enzyme has no detectable effect on nuclear envelope assembly and expansion, but is crucially required for nuclear envelope breakdown and lamin depolymerization during mitosis. Lpin-1 acts independently of nuclear pore complexes and the transmembrane nucleoporin gp210 | Caenorhabditis elegans |
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