Cloned (Comment) | Organism |
---|---|
full-length cDNAs for human lipin-1 transferred to the pCMV/V5-DEST vector. Plasmid DNA transformed and amplified using DH5alpha bacteria, and transfection of L6 myocytes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | triceps muscle | Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
lipin-1 | - |
Homo sapiens |
lipin-1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | mRNA in rat triceps muscle is increased by approximately 2fold after an acute bout of endurance swimming exercise. Lipin-1 mRNA expression in the triceps muscle, compared with that of the control muscle, significantly increases by 85% and 71% immediately after 3- and 6-h swimming exercise, respectively. Lipin-1 mRNA expression in rat triceps muscle is significantly elevated at 6 h after subcutaneous injections of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) by 82% or clenbuterol by 3fold, which are 5'-AMP-activated protein kinase and beta2-adrenergic receptor activators, respectively | up |
General Information | Comment | Organism |
---|---|---|
physiological function | ectopic expression of lipin-1 in L6 myotube increases carnitine palmitoyltransferase-1 and delta-aminolevulinate synthase gene expression | Homo sapiens |
physiological function | enhanced expression of lipin-1 is involved in exercise-induced mitochondrial enzyme adaptations, possibly through 5'-AMP-activated protein kinase- and beta2-adrenergic receptor-related mechanisms | Rattus norvegicus |