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Literature summary for 3.1.3.4 extracted from

  • Higashida, K.; Higuchi, M.; Terada, S.
    Potential role of lipin-1 in exercise-induced mitochondrial biogenesis (2008), Biochem. Biophys. Res. Commun., 374, 587-591.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
full-length cDNAs for human lipin-1 transferred to the pCMV/V5-DEST vector. Plasmid DNA transformed and amplified using DH5alpha bacteria, and transfection of L6 myocytes Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information triceps muscle Rattus norvegicus
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skeletal muscle
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
lipin-1
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Homo sapiens
lipin-1
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus mRNA in rat triceps muscle is increased by approximately 2fold after an acute bout of endurance swimming exercise. Lipin-1 mRNA expression in the triceps muscle, compared with that of the control muscle, significantly increases by 85% and 71% immediately after 3- and 6-h swimming exercise, respectively. Lipin-1 mRNA expression in rat triceps muscle is significantly elevated at 6 h after subcutaneous injections of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) by 82% or clenbuterol by 3fold, which are 5'-AMP-activated protein kinase and beta2-adrenergic receptor activators, respectively up

General Information

General Information Comment Organism
physiological function ectopic expression of lipin-1 in L6 myotube increases carnitine palmitoyltransferase-1 and delta-aminolevulinate synthase gene expression Homo sapiens
physiological function enhanced expression of lipin-1 is involved in exercise-induced mitochondrial enzyme adaptations, possibly through 5'-AMP-activated protein kinase- and beta2-adrenergic receptor-related mechanisms Rattus norvegicus