Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.4 extracted from

  • Grimsey, N.; Han, G.S.; OHara, L.; Rochford, J.J.; Carman, G.M.; Siniossoglou, S.
    Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 (2008), J. Biol. Chem., 283, 29166-29174.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Cloned(Commentary)

Cloned (Comment) Organism
expression of lipin-1 in HeLa M cells Homo sapiens
expression of lipin-2 in HeLa M cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity Homo sapiens
additional information mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3-sn-phosphatidate + H2O Homo sapiens lipin-1 is negatively regulated by phosphorylation during mitosis a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
a 3-sn-phosphatidate + H2O Mus musculus lipin-2 is negatively regulated by phosphorylation during mitosis a 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14693
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity Homo sapiens
phosphoprotein mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue PAP1 activity increases during adipogenesis Mus musculus
-
adipose tissue PAP1 activity increases during adipogenesis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 3-sn-phosphatidate + H2O
-
 Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
a 3-sn-phosphatidate + H2O
-
 Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
a 3-sn-phosphatidate + H2O lipin-1 is negatively regulated by phosphorylation during mitosis Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
a 3-sn-phosphatidate + H2O lipin-2 is negatively regulated by phosphorylation during mitosis Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
lipin 1
-
 Homo sapiens
lipin 2
-
 Mus musculus
PAP1
-
 Mus musculus
PAP1
-
 Homo sapiens
phosphatidate phosphatase
-
 Mus musculus
phosphatidate phosphatase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Homo sapiens