Cloned (Comment) | Organism |
---|---|
expression of presqualene diphosphate phosphatase in COS-7 cells, co-expression with CTP:phosphocholine cytidylyltransferase-alpha | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | presqualene diphosphate phosphatase, i.e. PA-PSP, overexpression accelerates the synthesis of phosphatidylcholine and causes accumulation of triacylglycerol with concomitant decrease in the rate of phosphatidylinositol synthesis. Co-expression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhances the effect of PA-PSP on phosphatidylcholine levels, yet attenuates its effect on triacylglycerol, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | the enzyme active site exposed to the cytosolic side of the membrane | Homo sapiens | 5789 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32400 | - |
x * 32400, recombinant PA-PSP, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3-sn-phosphatidate + H2O | Homo sapiens | phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols | a 1,2-diacyl-sn-glycerol + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3-sn-phosphatidate + H2O | phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols | Homo sapiens | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
a 3-sn-phosphatidate + H2O | the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP | Homo sapiens | a 1,2-diacyl-sn-glycerol + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32400, recombinant PA-PSP, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PA-PSP | - |
Homo sapiens |
presqualene diphosphate phosphatase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |