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Literature summary for 3.1.3.4 extracted from

  • Burgdorf, C.; Prey, A.; Richardt, G.; Kurz, T.
    A HPLC-fluorescence detection method for determination of phosphatidic acid phosphohydrolase activity: application in human myocardium (2008), Anal. Biochem., 374, 291-297.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NEM 70% inhibition of isozyme PAP-1; 70% inhibition of isozyme PAP-1, 30% inhibition of isozyme PAP-2 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate pH 7.5, 37°C, crude enzyme preparation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mg2+ isozyme PAP-1, dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C ?
-
?
additional information Rattus norvegicus phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes PAP-1 and PAP-2
-
Rattus norvegicus
-
isozyme PAP-2
-
Rattus norvegicus
-
isozymes PAP-1 and PAP-2
-

Source Tissue

Source Tissue Comment Organism Textmining
heart approximately fourfold higher in ventricular myocardium than in atrial tissue Homo sapiens
-
heart ventricular and atrial tissue, isozyme PAP-2 Rattus norvegicus
-
heart ventricular and atrial tissue, isozymes PAP-1 and PAP-2 Rattus norvegicus
-
myocardium
-
Homo sapiens
-
myocardium isozyme PAP-2 Rattus norvegicus
-
myocardium isozymes PAP-1 and PAP-2 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
development of a HPLC-fluorescence detection method, overview Homo sapiens
additional information
-
development of a HPLC-fluorescence detection method, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate deirvative Homo sapiens 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate
-
?
2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate deirvative Rattus norvegicus 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate
-
?
2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate derivative Rattus norvegicus 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate
-
?
additional information phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C Homo sapiens ?
-
?
additional information phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PAP-1
-
Homo sapiens
PAP-1
-
Rattus norvegicus
PAP-2
-
Homo sapiens
PAP-2
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens
7.5
-
assay at Rattus norvegicus