Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of LPP-3 in HEK293 cells and in Xenopus laevis dorsal blastomeres of embryos causing a mild ventralizing effect | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of several mouse models overexpressing or lacking LPP isozymes, e.g. overexpression of LPP-1 leads to defects in fertility in female mice and to increased accumulation of diacylglycerol, LPP-2 knockout mice are fertile and viable, whereas LPP-3 knockout mice show a severe phenotype failing to form a chorio-allantoic placenta and yolk sac vasculature, in addition, mutant embryos show a shortening of the anterior-posterior axis, overview, introduction of LPP-1 into Drosophila melanogaster germ cells has no effect on the germ-cell-specific factor in vivo | Mus musculus |
additional information | introduction of LPP-3 into Drosophila melanogaster germ cells causes aberrant migration and germ cell death | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the enzymes act intra- and extracellularly | Drosophila melanogaster | - |
- |
additional information | the enzymes act intra- and extracellularly | Mus musculus | - |
- |
additional information | the enzymes act intra- and extracellularly | Rattus norvegicus | - |
- |
additional information | the enzymes act intra- and extracellularly | Homo sapiens | - |
- |
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
plasma membrane | isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion | Homo sapiens | 5886 | - |
plasma membrane | the isozyme LPP-1 is partly expressed in the plama membrane with its C-terminal end located on the cell surface | Drosophila melanogaster | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | Drosophila melanogaster | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Mus musculus | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Rattus norvegicus | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Homo sapiens | - |
monoacylglycerol + phosphate | - |
? | |
additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview | ? | - |
? | |
additional information | Mus musculus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | ? | - |
? | |
additional information | Rattus norvegicus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | ? | - |
? | |
additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | ? | - |
? | |
additional information | Drosophila melanogaster | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview | ? | - |
? | |
additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | ? | - |
? | |
sphingosine 1-phosphate + H2O | Drosophila melanogaster | - |
sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | Mus musculus | - |
sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | Rattus norvegicus | - |
sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | Homo sapiens | - |
sphingosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
genes Wun and Wun2 | - |
Homo sapiens | Q6T4P5 | LPR-3; LPR-3 | - |
Homo sapiens | Q7Z2D5 | PRG-1 or LPR-4; PRG-1 or LPR-4 | - |
Homo sapiens | Q8TBJ4 | PRG-3 or LPR-1; isozyme PRG-3 or LPR-1 | - |
Homo sapiens | Q96GM1 | LPR-2 or PRG-4; PRG-4 or LPR-2 | - |
Mus musculus | - |
several isozymes, e.g. isozyme PAP2A, i.e. LPP-1 | - |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation | Drosophila melanogaster |
glycoprotein | N-glycosylation | Mus musculus |
glycoprotein | N-glycosylation | Rattus norvegicus |
glycoprotein | N-glycosylation | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate | the active site of plasma membrane LPP-1, LPP-2, and LPP-3 is outside the cell, the conserved phosphatase family amino acids are essential for catalytic activity | Drosophila melanogaster |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
bladder | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
brain | LPP-2 predominantly | Homo sapiens | - |
heart | - |
Homo sapiens | - |
heart | LPP-1a predominantly | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
intestinal mucosa | epithelial differentiation of intestinal mucosa leads to increased Dri-42/LPP-3 expression | Rattus norvegicus | - |
kidney | - |
Homo sapiens | - |
kidney | LPP-1 predominantly | Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | LPP-1 predominantly | Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung | LPP-1 predominantly | Homo sapiens | - |
additional information | tissue distribution | Homo sapiens | - |
neuron | expression of PRG-1 | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pancreas | LPP-2 predominantly | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
placenta | LPP-1 predominantly | Homo sapiens | - |
placenta | LPP-2 predominantly | Homo sapiens | - |
prostate adenocarcinoma cell | LPP-1 | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide 1-phosphate + H2O | - |
Drosophila melanogaster | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Mus musculus | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Rattus norvegicus | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Drosophila melanogaster | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview | Homo sapiens | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | Mus musculus | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | Rattus norvegicus | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | Homo sapiens | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview | Drosophila melanogaster | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview | Homo sapiens | ? | - |
? | |
additional information | Wunen does not interact with Wunen2 | Drosophila melanogaster | ? | - |
? | |
phosphatidic acid + H2O | - |
Drosophila melanogaster | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Drosophila melanogaster | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the LPPs contain three conserved active site domains and six conserved transmembrane domains | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
Dri-42 | i.e. LPP-3 | Rattus norvegicus |
lipid phosphate phosphatase | - |
Drosophila melanogaster |
lipid phosphate phosphatase | - |
Mus musculus |
lipid phosphate phosphatase | - |
Rattus norvegicus |
lipid phosphate phosphatase | - |
Homo sapiens |
lipid phosphate phosphatase-related protein | - |
Drosophila melanogaster |
lipid phosphate phosphatase-related protein | - |
Mus musculus |
lipid phosphate phosphatase-related protein | - |
Rattus norvegicus |
lipid phosphate phosphatase-related protein type 1 | - |
Homo sapiens |
lipid phosphate phosphatase-related protein type 2 | - |
Homo sapiens |
lipid phosphate phosphatase-related protein type 3 | - |
Homo sapiens |
lipid phosphate phosphatase-related protein type 4 | - |
Homo sapiens |
LPP | - |
Drosophila melanogaster |
LPP | - |
Mus musculus |
LPP | - |
Rattus norvegicus |
LPP | - |
Homo sapiens |
LPPR2 | - |
Homo sapiens |
LPR | - |
Drosophila melanogaster |
LPR | - |
Mus musculus |
LPR | - |
Rattus norvegicus |
LPR-1 | - |
Homo sapiens |
LPR-2 | - |
Homo sapiens |
LPR-3 | - |
Homo sapiens |
LPR-4 | - |
Homo sapiens |
PAP | - |
Mus musculus |
plasticity related gene 1 | - |
Homo sapiens |
plasticity related gene 3 | - |
Homo sapiens |
plasticity related gene 4 | - |
Homo sapiens |
PRG-1 | - |
Homo sapiens |
PRG-3 | - |
Homo sapiens |
Wunen | - |
Drosophila melanogaster |
Wunen2 | - |
Drosophila melanogaster |