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Literature summary for 3.1.3.4 extracted from

  • English, D.; Martin, M.; Harvea, K.A.; Akard, L.P.; Allen, R.; Widlanski, T.S.; Garcia, J.G.; Siddiqui, R.A.
    Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase (1997), Biochem. J., 324, 941-950.
No PubMed abstract available
Search for more literature for 3.1.3.4

Inhibitors

Inhibitors Comment Organism Structure
dihydrosphingosine
-
 Homo sapiens
dimethylsphingosine
-
 Homo sapiens
F- NaF Homo sapiens
Mg2+ MgCl2 Homo sapiens
NEM no inhibition Homo sapiens
phosphatidic acid competitive inhibition Homo sapiens
propanolol
-
 Homo sapiens
sphingosine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4
-
 dioctanoyl phosphatidic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may play an important role in regulating inflammatory cell responses to extracellular phosphatidic acid in biological system ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1175
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
didecanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-didecanoyl-sn-glycerol + phosphate
-
 ?
dihexanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dihexanoyl-sn-glycerol + phosphate
-
 ?
dimyristoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dimyristoyl-sn-glycerol + phosphate
-
 ?
dioctanoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dioctanoyl-sn-glycerol + phosphate
-
 ?
dioleoyl phosphatidic acid + H2O
-
 Homo sapiens 1,2-dioleoyl-sn-glycerol + phosphate
-
 ?
dipalmitoyl phosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
lysophosphatidate + H2O
-
 Homo sapiens ?
-
 ?
additional information both long and short chain lysophosphatidic acids are hydrolyzed at rates comparable with that observed for short chain phosphatidic acids Homo sapiens ?
-
 ?
additional information the enzyme may play an important role in regulating inflammatory cell responses to extracellular phosphatidic acid in biological system Homo sapiens ?
-
 ?
octanoyl lysophosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
oleoyl phosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 45000-52000, SDS-PAGE Homo sapiens