Literature summary for 3.1.3.3 extracted from

Kim, H.Y.; Heo, Y.S.; Kim, J.H.; Park, M.H.; Moon, J.; Kim, E.; Kwon, D.; Yoon, J.; Shin, D.; Jeong, E.J.; Park, S.Y.; Lee, T.G.; Jeon, Y.H.; Ro, S.; Cho, J.M.; Hwang, K.Y.
Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase (2002), J. Biol. Chem., 277, 46651-46658.

Search for more literature for 3.1.3.3

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging-drop vapour-diffusion method	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E29D	less than 5% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
E29Q	inactive mutant enzyme	Homo sapiens
N133A	about 25% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
N133D	about 130% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
R202A	inactive mutant enzyme	Homo sapiens
R202K	less than 5% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
R65A	inactive mutant enzyme	Homo sapiens
R65K	inactive mutant enzyme	Homo sapiens
S23A	about 50% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
S23T	about 20% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
T182S	about 5% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens
T182V	about 75% of the activity of wild-type enzyme with L-phosphoserine as substrate	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phosphoserine + H2O	-	Homo sapiens	L-serine + phosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)