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Literature summary for 3.1.3.2 extracted from

  • Valizadeh, M.; Schenk, G.; Nash, K.; Oddie, G.W.; Guddat, L.W.; Hume, D.A.; de Jersey, J.; Burke, T.R.; Hamilton, S.
    Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases (2004), Arch. Biochem. Biophys., 424, 154-162.
    View publication on PubMed
Search for more literature for 3.1.3.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in Spodopetra frugiperda Sf9 cells using the baculovirus infection system Mus musculus
expression in Spodopetra frugiperda Sf9 cells using the baculovirus infection system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Homo sapiens
4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Ipomoea batatas
4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Mus musculus
4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Phaseolus vulgaris
4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Sus scrofa
4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Homo sapiens
4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Ipomoea batatas
4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Mus musculus
4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Phaseolus vulgaris
4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Sus scrofa
additional information inhibitor-enzyme interaction Homo sapiens
additional information inhibitor-enzyme interaction Ipomoea batatas
additional information inhibitor-enzyme interaction Mus musculus
additional information inhibitor-enzyme interaction Phaseolus vulgaris
additional information inhibitor-enzyme interaction Sus scrofa
phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Homo sapiens
phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Ipomoea batatas
phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Mus musculus
phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Phaseolus vulgaris
phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Phaseolus vulgaris
additional information
-
 additional information kinetics Mus musculus
additional information
-
 additional information kinetics Homo sapiens
additional information
-
 additional information kinetics Ipomoea batatas
additional information
-
 additional information kinetics Sus scrofa
0.006
-
 Fmoc-EEY(P)AA pH 2.5, 25°C Sus scrofa
0.008
-
 Fmoc-EY(P)A pH 2.5, 25°C Sus scrofa
0.048
-
 Fmoc-EY(P)A pH 4.9, 25°C Sus scrofa
0.075
-
 Fmoc-EEY(P)AA pH 4.9, 25°C Sus scrofa
0.12
-
 Fmoc-AAY(P)AA pH 4.9, 25°C Sus scrofa
0.14
-
 EEY(P)AA pH 2.5, 25°C Sus scrofa
0.31
-
 EEY(P)AA pH 4.9, 25°C Sus scrofa
0.95
-
 Fmoc-KKAY(P)AA pH 4.9, 25°C Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Iron required Mus musculus
Iron required Homo sapiens
Iron required Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Ipomoea batatas
-
 sweet potato
-
Mus musculus
-
-
-
Phaseolus vulgaris
-
 red kidney bean
-
Sus scrofa P09889
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme to over 95% purity Mus musculus
recombinant enzyme to over 95% purity Homo sapiens
to over 95% purity Phaseolus vulgaris
to over 95% purity Ipomoea batatas
to over 95% purity Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
allantoic fluid
-
 Sus scrofa
-
seed
-
 Phaseolus vulgaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Phaseolus vulgaris 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Mus musculus 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Ipomoea batatas 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Sus scrofa 4-nitrophenol + phosphate
-
 ?
EEY(P)AA + H2O
-
 Sus scrofa EEYAA + phosphate
-
 ?
Fmoc-AAY(P)AA + H2O
-
 Sus scrofa Fmoc-AAYAA + phosphate
-
 ?
Fmoc-EEY(P)AA + H2O
-
 Sus scrofa Fmoc-EEYAA + phosphate
-
 ?
Fmoc-EY(P)A + H2O
-
 Sus scrofa Fmoc-EYA + phosphate
-
 ?
Fmoc-KKAY(P)AA + H2O
-
 Sus scrofa Fmoc-KKAYAA + phosphate
-
 ?
Fmoc-KKY(P)AA + H2O
-
 Sus scrofa Fmoc-KKYAA + phosphate
-
 ?
additional information substrate specificity Sus scrofa ?
-
 ?
phospho-L-tyrosine + H2O
-
 Phaseolus vulgaris L-tyrosine + phosphate
-
 ?
phospho-L-tyrosine + H2O
-
 Mus musculus L-tyrosine + phosphate
-
 ?
phospho-L-tyrosine + H2O
-
 Homo sapiens L-tyrosine + phosphate
-
 ?
phospho-L-tyrosine + H2O
-
 Ipomoea batatas L-tyrosine + phosphate
-
 ?
phospho-L-tyrosine + H2O
-
 Sus scrofa L-tyrosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
purple acid phosphatase
-
 Phaseolus vulgaris
purple acid phosphatase
-
 Mus musculus
purple acid phosphatase
-
 Homo sapiens
purple acid phosphatase
-
 Ipomoea batatas
purple acid phosphatase
-
 Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
25
-
 Fmoc-EY(P)A pH 2.5, 25°C Sus scrofa
31
-
 Fmoc-EY(P)A pH 4.9, 25°C Sus scrofa
35
-
 Fmoc-EEY(P)AA pH 2.5, 25°C Sus scrofa
65
-
 EEY(P)AA pH 2.5, 25°C Sus scrofa
79
-
 EEY(P)AA pH 4.9, 25°C Sus scrofa
100
-
 Fmoc-AAY(P)AA pH 4.9, 25°C Sus scrofa
120
-
 Fmoc-EEY(P)AA pH 4.9, 25°C Sus scrofa
170
-
 Fmoc-KKAY(P)AA pH 4.9, 25°C Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3 3.5 highest catalytic efficiency Phaseolus vulgaris
3 3.5 highest catalytic efficiency Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
3 6 pH profile Sus scrofa