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Literature summary for 3.1.3.1 extracted from

  • Mirhashemi, S.; Moshtaghie, A.; Ani, M.; Aarabi, M.
    In vivo and in vitro studies of kinetic changes of serum, liver and brain high and low molecular weight alkaline phosphatase following aluminium exposure in rat (2010), Asian J. Biochem., 5, 1-11.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Al3+ inhibits high molecular weight and low molecular weight alkaline phosphatase non-competitively Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
serum
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
high molecular weight alkaline phosphatase
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Rattus norvegicus
low molecular weight alkaline phosphatase
-
Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
high molecular weight alkaline phosphatase is less heat and urea stable than low molecular weight alkaline phosphatase Rattus norvegicus
additional information
-
low molecular weight alkaline phosphatase is more heat and urea stable than high molecular weight alkaline phosphatase Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in decreased expression of brain and liver alkaline phosphatase. Gel filtration experiments disclose a high level of high molecular weight alkaline phosphatase compared to control animals down
Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in decreased expression of brain and liver alkaline phosphatase. Gel filtration studies show a significant reduction in low molecular weight alkaline phosphatase compared to control groups down
Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in an increased expression of serum alkaline phosphatase up