Application | Comment | Organism |
---|---|---|
medicine | a circulating factor causes pyrophosphate deficiency by regulating TNAP activity and vascular calcification in renal failure may result from the action of this factor | Mus musculus |
medicine | a circulating factor causes pyrophosphate deficiency by regulating TNAP activity and vascular calcification in renal failure may result from the action of this factor | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | hydrolysis of pyrophosphate by rat aortic rings is reduced about half in aortas from mice lacking TNAP | Mus musculus |
additional information | TNAP activity increases twofold in intact aortas and in aortic homogenates from rats made uremic by feeding adenine or by 5/6 nephrectomy. Immunoblotting showsS an increase in protein abundance but there is no increase in TNAP mRNA. An increase in TNAP activity and pyrophosphate hydrolysis also occurres when aortic rings from normal rats are incubated with uremic rat plasma | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
levamisole | hydrolysis of pyrophosphate by rat aortic rings is inhibited about half by the nonspecific alkaline phosphatase inhibitor levamisole. Hydrolysis is increased in aortic rings from uremic rats and all of this increase is inhibited by levamisole | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
tissue-nonspecific alkaline phosphatase | - |
Mus musculus |
tissue-nonspecific alkaline phosphatase | - |
Rattus norvegicus |
TNAP | - |
Mus musculus |
TNAP | - |
Rattus norvegicus |