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Literature summary for 3.1.3.1 extracted from

  • Claassen, H.; Moenig, H.; Sel, S.; Werner, J.A.; Paulsen, F.
    Androgen receptors and gender-specific distribution of alkaline phosphatase in human thyroid cartilage (2006), Histochem. Cell Biol., 126, 381-388.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involvement of androgen receptor positive chondrocytes in thyroid cartilage mineralization, probably by a testosterone-linked stimulation of alkaline phosphatase ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
thyroid cartilage enzyme activity of alkaline phosphatase is not observed in chondrocytes of the subperichondral and central cartilage layer of thyroid cartilage prior to cartilage mineralization. In the thyroid cartilage of a male foetus from 23rd gestational week, as well as from a 9-year-old girl and an 11-year-old boy, the enzymohistochemical reaction is negative. Beginning approximately at the middle of the second decade, the reaction product of the enzyme alkaline phosphatase is detected in distinct chondrocytes in the neighbourhood of mineralized cartilage areas or within the mineralized cartilage. In a comparison of aged-matched thyroid cartilages, male thyroid cartilage often contains more chondrocytes with a positive enzymohistochemical reaction for alkaline phosphatase than samples from females Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involvement of androgen receptor positive chondrocytes in thyroid cartilage mineralization, probably by a testosterone-linked stimulation of alkaline phosphatase Homo sapiens ?
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?