Literature summary for 3.1.3.1 extracted from

Vaisman, D.N.; McCarthy, A.D.; Cortizo, A.M.
Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations (2005), Biol. Trace Elem. Res., 104, 131-140.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alendronate	0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition	Rattus norvegicus
pamidronate	0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition	Rattus norvegicus
zoledronate	0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	metalloprotein contains Zn2+ and Mg2+, both of which are necessary for catalytic function	Rattus norvegicus
Zn2+	metalloprotein contains Zn2+ and Mg2+, both of which are necessary for catalytic function	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
UMR-106 cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p-nitrophenyl phosphate + H2O	-	Rattus norvegicus	p-nitrophenol + phosphate	-	?

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Release 2023.1 (January 2023)