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Literature summary for 3.1.26.4 extracted from

  • Budihas, S.R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M.K.; Parniak, M.A.; Crouch, R.J.; McMahon, J.B.; Beutler, J.A.; Le Grice, S.F.J.
    Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones (2005), Nucleic Acids Res., 33, 1249-1256.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.4

Inhibitors

Inhibitors Comment Organism Structure
alpha-thujaplicin i.e. 2-hydroxy-3-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, slight inhibition Escherichia coli
alpha-thujaplicin i.e. 2-hydroxy-3-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Homo sapiens
beta-thujaplicin i.e. 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, slight inhibition Escherichia coli
beta-thujaplicin i.e. 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Homo sapiens
beta-thujaplicinol i.e. 2,7-dihydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Escherichia coli
beta-thujaplicinol i.e. 2,7-dihydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Homo sapiens
gamma-thujaplicin i.e. 2-hydroxy-5-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, slight inhibition Escherichia coli
gamma-thujaplicin i.e. 2-hydroxy-5-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Homo sapiens
manicol i.e. 1,2,3,4-tetrahydro-2,7-dihydroxy-9-methyl-2-(1-methylethyl)-6H-benzocyclohepten-6-one Escherichia coli
manicol i.e. 1,2,3,4-tetrahydro-2,7-dihydroxy-9-methyl-2-(1-methylethyl)-6H-benzocyclohepten-6-one Homo sapiens
additional information selectivity of tropolone derivatives for RNase H, IC50 values, inhibition mechanism, overview Escherichia coli
additional information selectivity of tropolone derivatives for RNase H, IC50 values, inhibition mechanism, overview Homo sapiens
nootkatin i.e. 2-hydroxy-5-(3-methyl-2-butenyl)-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one, slight inhibition Escherichia coli
nootkatin i.e. 2-hydroxy-5-(3-methyl-2-butenyl)-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Homo sapiens
tropolone i.e. 2-hydroxy-2,4,6-cycloheptatrien-1-one, slight inhibition Escherichia coli
tropolone i.e. 2-hydroxy-2,4,6-cycloheptatrien-1-one Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O
-
 Escherichia coli ?
-
 ?
DNA-RNA hybrid + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ribonuclease H
-
 Escherichia coli
ribonuclease H
-
 Homo sapiens
RNase H
-
 Escherichia coli
RNase H
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Escherichia coli
additional information
-
 additional information
-
 Homo sapiens