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Literature summary for 3.1.21.4 extracted from
- Role of magnesium ions in DNA recognition by the EcoRV restriction endonuclease (2011), FEBS Lett., 585, 2739-2743.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | EcoRV binds two magnesium ions in the active site. One of these ions, Mg2+A, binds to the phosphate group where the cleavage occurs and is required for catalysis. The other, Mg2+B, is crucial for achieving a tightly bound protein-DNA complex and stabilizing a conformation that allows cleavage, structure analysis, molecular dynamics simulations, overview | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | schematic view of the hydrogen-bond interactions of the DNA with each subunit of the protein for the 2TA and 1TA complexes, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | schematic view of the hydrogen-bond interactions of the DNA with each subunit of the protein for the 2TA and 1TA complexes, overview | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EcoRV | - |
Escherichia coli |
| restriction endonuclease EcoRV | - |
Escherichia coli |
| type II restriction endonuclease | - |
Escherichia coli |
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