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Literature summary for 3.1.21.1 extracted from

  • Zhu, B.; Gong, Y.; Chen, P.; Zhang, H.; Zhao, T.; Li, P.
    Increased DNase I activity in diabetes might be associated with injury of pancreas (2014), Mol. Cell. Biochem., 393, 23-32.
    View publication on PubMed

Application

Application Comment Organism
medicine patients with type 2 diabetes show a significant elevation of DNase I activity in serum, and increase in DNase I expression is observed in the pancreas of diabetic persons Homo sapiens
medicine rats with diabetes induced by streptozotocin injection and high fat diet show a significant elevation of DNase I activity in serum, and increase in DNase I expression is observed in the pancreas of diabetic rats. High glucose induces both DNase I and caspase-3 expression and at the same time increases apoptosis rate of INS-1 cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
pancreas
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Rattus norvegicus
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serum
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Homo sapiens
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serum
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Rattus norvegicus
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Expression

Organism Comment Expression
Rattus norvegicus high glucose induces both DNase I and caspase-3 up