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Literature summary for 3.1.21.1 extracted from

  • Choi, C.H.; Hyun, S.H.; Kim, J.; Lee, Y.C.; Seol, S.Y.; Cho, D.T.; Lee, J.C.
    Nuclear translocation and DNAse I-like enzymatic activity of Acinetobacter baumannii outer membrane protein A (2008), FEMS Microbiol. Lett., 288, 62-67.
    View publication on PubMed
Search for more literature for 3.1.21.1

Cloned(Commentary)

Cloned (Comment) Organism
into the pET28a expression vector and overexpressed in Escherichia coli BL21 (DE3). His-tagged OmpA expressed in HEp-2 cells Acinetobacter baumannii

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the intracellular recombinant OmpA is degraded into several forms of subfragments in the cytosol of the host and two subfragments of recombinant OmpA are translocated into the nuclei Acinetobacter baumannii
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outer membrane
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 Acinetobacter baumannii 19867
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Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ exhibits divalent cation-dependent endonuclease activity Acinetobacter baumannii
Mg2+ exhibits divalent cation-dependent endonuclease activity Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Acinetobacter baumannii OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity ?
-
 ?
additional information Acinetobacter baumannii ATCC 19606T OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
 strain ATCC19606T
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Acinetobacter baumannii ATCC 19606T
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 strain ATCC19606T
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity Acinetobacter baumannii ?
-
 ?
additional information OmpA is a potential virulence factor involved in the induction of host cell death. Acinetobacter baumannii can secrete OmpA during colonization and infection. The pathogenic strategy is that OmpA translocates into the nuclei of host cells and degrades chromosomal DNA by DNAse I-like enzymatic activity Acinetobacter baumannii ATCC 19606T ?
-
 ?
Xenopus laevis DNA + H2O degrades chromosomal DNA with the characteristic DNA ladders and induces apoptosis of Xenopus embryos Acinetobacter baumannii 5'-phosphooligonucleotides + ?
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 ?
Xenopus laevis DNA + H2O degrades chromosomal DNA with the characteristic DNA ladders and induces apoptosis of Xenopus embryos Acinetobacter baumannii ATCC 19606T 5'-phosphooligonucleotides + ?
-
 ?

Synonyms

Synonyms Comment Organism
OmpA
-
 Acinetobacter baumannii
outer membrane protein A
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 Acinetobacter baumannii