Cloned (Comment) | Organism |
---|---|
expression in MCF-7 cell | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
A144Y | mutant with extremely reduced actin binding capacity. Induction of apoptosis or necrosis by staurosporine or oxidative stress results in faster chromatin fragmentation in mutant cells. Inclusion of actin under these conditions inhibits chromatin degradation in wild-type, but not in mutant | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actin | inhibition of enzyme by actin may serve as a self-protection mechanism against premature DNA degradtion during cell damage | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P49183 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | interaction of enzyme with actin and inhibition by actin. Inhibition may serve as a self-protection mechanism against premature DNA degradtion during cell damage | Mus musculus |