Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.21.1 extracted from

  • Eulitz, D.; Mannherz, H.G.
    Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell death (2007), Apoptosis, 12, 1511-1521.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in MCF-7 cell Mus musculus

Protein Variants

Protein Variants Comment Organism
A144Y mutant with extremely reduced actin binding capacity. Induction of apoptosis or necrosis by staurosporine or oxidative stress results in faster chromatin fragmentation in mutant cells. Inclusion of actin under these conditions inhibits chromatin degradation in wild-type, but not in mutant Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
actin inhibition of enzyme by actin may serve as a self-protection mechanism against premature DNA degradtion during cell damage Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P49183
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-

Subunits

Subunits Comment Organism
More interaction of enzyme with actin and inhibition by actin. Inhibition may serve as a self-protection mechanism against premature DNA degradtion during cell damage Mus musculus