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Literature summary for 3.1.21.1 extracted from
- Human deoxyribonucleases (2004), Biochemistry (Moscow), 69, 587-601.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | decrease in DNase activity in blood correlates with chronic pancreatitis, stomach cancer and glomerulonephritis | Homo sapiens |
| diagnostics | increase in DNase activity in blood was observed during development of breast cancer | Homo sapiens |
| medicine | improvement of respiratory tract functioning in patients with cystic fibrosis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Homo sapiens |  |
| gamma-actin | - |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 1 mM optimal concentration | Homo sapiens | |
| Mg2+ | 10 mM optimal concentration | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
calculated from sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded DNA + H2O | Homo sapiens | - |
5'-phosphooligonucleotides + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 11.8% carbohydrate content | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded DNA + H2O | - |
Homo sapiens | 5'-phosphooligonucleotides + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deoxyribonuclease I | - |
Homo sapiens |
| DNase I | - |
Homo sapiens |
| hDNase I | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000013 | - |
gamma-actin | - |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | pI values vary from 3.5-4.3 due to single nucleotide polymorphism | - |
3.5 |
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