Literature summary for 3.1.2.22 extracted from

Zhang, Z.; Lee, Y.C.; Kim, S.J.; Choi, M.S.; Tsai, P.C.; Xu, Y.; Xiao, Y.J.; Zhang, P.; Heffer, A.; Mukherjee, A.B.
Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL (2005), Hum. Mol. Genet., 15, 337-346.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	in palmitoyl-protein thioesterase-1-knockout mice (that mimic human infantile neuronal ceroid lipofuscinosis) the endoplasmic reticulum in the brain cells is structurally abnormal. Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in human infantile neuronal ceroid lipofuscinosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	in palmitoyl-protein thioesterase-1-knockout mice (that mimic human infantile neuronal ceroid lipofuscinosis) the endoplasmic reticulum in the brain cells is structurally abnormal. Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in human infantile neuronal ceroid lipofuscinosis	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
palmitoyl-protein thioesterase-1	-	Mus musculus
PPT1	-	Mus musculus

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Release 2023.1 (January 2023)