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Literature summary for 3.1.2.22 extracted from
- Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain (1999), Neurosci. Lett., 265, 53-56.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus norvegicus | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the enzyme is essential for both development and maintenance of cortical neurons, enzyme deficiency causes severe neurodegenerative disorders by loss of cortical neurons | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
gene ppt | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression of enzyme is developmentally regulated, with increasing expression during maturation of the CNS, reaching the maximum in young adulthood | Rattus norvegicus | - |
| cerebrum | - |
Rattus norvegicus | - |
| embryo | - |
Rattus norvegicus | - |
| eye | - |
Rattus norvegicus | - |
| liver | enzyme expression slowly decreases during maturation | Rattus norvegicus | - |
| neuroepithelium | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is essential for both development and maintenance of cortical neurons, enzyme deficiency causes severe neurodegenerative disorders by loss of cortical neurons | Rattus norvegicus | ? | - |
? | |
| palmitoyl-[protein] + H2O | hydrolysis of long-chain fatty acids from S-acylated proteins and CoA | Rattus norvegicus | palmitate + protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Palmitoyl-protein thioesterase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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