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Literature summary for 3.1.2.22 extracted from

  • Suopanki, J.; Lintunen, M.; Lahtinen, H.; Haltia, M.; Panula, P.; Baumann, M.; Tyynela, J.
    Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1 (2002), Neurobiol. Dis., 10, 247-257.
    View publication on PubMed
Search for more literature for 3.1.2.22

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information colocalization of the enzyme with the synaptic membrane marker is enhanced after epileptic seizures Rattus norvegicus
-
-
synapse cortical, in synaptic junctions of epileptic rats, nearly not in non-epileptic ones Rattus norvegicus 45202
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synaptic vesicle
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 Rattus norvegicus 8021
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus epileptic seizures in adult rats lead to progressive and remarkable increase in enzyme activity inlimbic areas of the brain, the enzyme may protect neurons from excitotoxicity and have a role in synaptic plasticity, enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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hippocampus
-
 Rattus norvegicus
-
neuron pyramidal Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information epileptic seizures in adult rats lead to progressive and remarkable increase in enzyme activity inlimbic areas of the brain, the enzyme may protect neurons from excitotoxicity and have a role in synaptic plasticity, enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL Rattus norvegicus ?
-
 ?
palmitoyl-[protein] + H2O
-
 Rattus norvegicus palmitate + protein
-
 ?

Subunits

Subunits Comment Organism
? x * 35000-37000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
palmitoyl-protein thioesterase 1
-
 Rattus norvegicus
PPT1
-
 Rattus norvegicus