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Literature summary for 3.1.2.22 extracted from
- Detection of eight novel palmitoyl protein thioesterase (PPT) mutations underlying infantile neuronal ceroid lipofuscinosis (INCL;CLN1) (2000), Hum. Mutat., 15, 273-279.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ppt, DNA sequence determnation and analysis, identification of 8 natural mutations of different origins leading to enzyme deficiency | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme deficiency causes the infantile form of neuronal ceroid lipofuscinosis INCL, a progressive encephalopathyof children | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme deficiency causes the infantile form of neuronal ceroid lipofuscinosis INCL, a progressive encephalopathyof children | Homo sapiens | ? | - |
? | |
| palmitoyl-[protein] + H2O | - |
Homo sapiens | palmitate + protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| palmitoyl protein thioesterase | - |
Homo sapiens |
| PPT | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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