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Literature summary for 3.1.2.22 extracted from

  • Lukacs, Z.; Santavuori, P.; Keil, A.; Steinfeld, R.; Kohlschutter, A.
    Rapid and simple assay for the determination of tripeptidyl peptidase and palmitoyl protein thioesterase activities in dried blood spots (2003), Clin. Chem., 49, 509-512.
    View publication on PubMed
Search for more literature for 3.1.2.22

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by EDTA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PPT1 deficiency causes, together with tripeptidyl peptidase 1 deficiency, progressive neurological disorder infantile neuronal ceroid lipofuscinosis, a group of at least 8 inherited, progressive encephalopathies that are characterized by lipofuscin-like inclusions in various tissues and have been classified as CNL1-CNL8 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 lysosomal enzyme forms PPT1
-

Reaction

Reaction Comment Organism Reaction ID
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
skin fibroblast very low or no activity Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O
-
 Homo sapiens 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
 ?
additional information enzyme assay development Homo sapiens ?
-
 ?
additional information PPT1 deficiency causes, together with tripeptidyl peptidase 1 deficiency, progressive neurological disorder infantile neuronal ceroid lipofuscinosis, a group of at least 8 inherited, progressive encephalopathies that are characterized by lipofuscin-like inclusions in various tissues and have been classified as CNL1-CNL8 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
palmitoyl protein thioesterase 1
-
 Homo sapiens
PPT1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at, room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
 assay at Homo sapiens