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Literature summary for 3.1.2.22 extracted from

  • Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.
    The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function (2002), Biochim. Biophys. Acta, 1583, 35-44.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Chloroquine inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells Homo sapiens
leupeptin inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells but has no direct inhibitory effect on the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphoblastoid cell line transformed by Epstein-Barr virus Homo sapiens
-
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder Homo sapiens ?
-
?
palmitoyl-[protein] + H2O
-
Homo sapiens palmitate + protein
-
?

Synonyms

Synonyms Comment Organism
palmitoyl-protein hydrolase
-
Homo sapiens
Palmitoyl-protein thioesterase
-
Homo sapiens
PPT
-
Homo sapiens
PPT1
-
Homo sapiens