Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloroquine | inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells | Homo sapiens | |
leupeptin | inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells but has no direct inhibitory effect on the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphoblastoid cell line | transformed by Epstein-Barr virus | Homo sapiens | - |
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder | Homo sapiens | ? | - |
? | |
palmitoyl-[protein] + H2O | - |
Homo sapiens | palmitate + protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
palmitoyl-protein hydrolase | - |
Homo sapiens |
Palmitoyl-protein thioesterase | - |
Homo sapiens |
PPT | - |
Homo sapiens |
PPT1 | - |
Homo sapiens |