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Literature summary for 3.1.13.4 extracted from

  • Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N.; Kossida, S.
    An integrated in silico approach to design specific inhibitors targeting human poly(A)-specific ribonuclease (2012), PLoS ONE, 7, e51113.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in silico model for catalytic mechanism and development of a 3D pharmacophore model. Residues Arg99 and Gln109 are involved in the regulation of catalysis. The natural preference of the enzyme for poly(A) is based on favorable biophysical electrostatic and hydrophobic interactions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
poly[2'-O-(2,4-dinitrophenyl)]poly-(A) competitive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95453
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.098
-
poly[2'-O-(2,4-dinitrophenyl)]poly-(A) pH not specified in the publication, temperature not specified in the publication Homo sapiens