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Literature summary for 3.1.13.4 extracted from

  • Dunn, E.F.; Hammell, C.M.; Hodge, C.A.; Cole, C.N.
    Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export (2005), Genes Dev., 19, 90-103.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.4

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged wild-type and mutant Pab1p in Xpo1-1 cells at 23°C and at 37°C leading to hyperadenylation of SSA4 mRNA, phenotype or recombinant cells, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information Pab1p contains a non-essential leucine-rich nuclear export signal and shuttles in an Xpo1/Gsp-1-dependent manner between the nucleus and the cytoplasm Saccharomyces cerevisiae
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nucleus PAN Saccharomyces cerevisiae 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis and 3' processing to export, Pab1p is essential, but several bypass suppressors exist, deletion leads to exosome-dependent retention at sites of transcription and inefficient nRNA release, e.g. of SSA4 mRNA, Pab1p and PAN interaction mechanism, overview ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis and 3' processing to export, Pab1p is essential, but several bypass suppressors exist, deletion leads to exosome-dependent retention at sites of transcription and inefficient nRNA release, e.g. of SSA4 mRNA, Pab1p and PAN interaction mechanism, overview Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
PAN
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 Saccharomyces cerevisiae
poly(A) nuclease complex
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 Saccharomyces cerevisiae