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Literature summary for 3.1.1.8 extracted from

  • Korabecny, J.; Musilek, K.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K.
    Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease (2010), Bioorg. Med. Chem. Lett., 20, 6093-6095.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
-
Homo sapiens
7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
-
Homo sapiens
N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
-
Homo sapiens
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
Homo sapiens
tacrine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
BChE
-
Homo sapiens
butyrylcholinesterase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000023
-
pH and temperature not specified in the publication Homo sapiens tacrine
0.00004
-
pH and temperature not specified in the publication Homo sapiens N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
0.00012
-
pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
0.00036
-
pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
0.001
-
pH and temperature not specified in the publication Homo sapiens N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
0.016
-
pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
0.021
-
pH and temperature not specified in the publication Homo sapiens 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
0.064
-
pH and temperature not specified in the publication Homo sapiens N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
0.07
-
pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
0.097
-
pH and temperature not specified in the publication Homo sapiens N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride