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Literature summary for 3.1.1.8 extracted from

  • Rivera-Becerril, E.; Joseph-Nathan, P.; Perez-Alvarez, V.M.; Morales-Rios, M.S.
    Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors (2008), J. Med. Chem., 51, 5271-5284.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-debromoflustramine B
-
Homo sapiens
(-)-debromoflustramine B
-
Homo sapiens
1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
-
Homo sapiens
3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
3a,8-dibenzyl-5-methoxy-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
5-methoxy-1-methyl-3a,8-bis(3-methylbut-2-en-1-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
8-benzyl-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
8-benzyl-5-methoxy-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
Homo sapiens
demethyldebromoflustramine B
-
Homo sapiens
galanthamine
-
Homo sapiens
huperzine A
-
Homo sapiens
additional information structure-activity studies of debromoflustramine B analogues as selective BChE inhibitors, molecular modeling, overview Homo sapiens
physostigmine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
butyrylcholinesterase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00026
-
-
Homo sapiens demethyldebromoflustramine B
0.00137
-
-
Homo sapiens (-)-debromoflustramine B
0.00172
-
-
Homo sapiens 1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.00259
-
-
Homo sapiens rac debromoflustramine B
0.00459
-
-
Homo sapiens 5-methoxy-1-methyl-3a,8-bis(3-methylbut-2-en-1-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.00589
-
-
Homo sapiens 3a,8-dibenzyl-5-methoxy-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.00754
-
-
Homo sapiens 8-benzyl-5-methoxy-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.01
-
-
Homo sapiens 8-benzyl-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.0221
-
-
Homo sapiens 3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
0.04998
-
-
Homo sapiens 1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
10
-
-
Homo sapiens (+)-debromoflustramine B