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Literature summary for 3.1.1.8 extracted from

  • Grigoryan, H.A.; Hambardzumyan, A.A.; Mkrtchyan, M.V.; Topuzyan, V.O.; Halebyan, G.P.; Asatryan, R.S.
    alpha,beta -Dehydrophenylalanine choline esters, a new class of reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase (2008), Chem. -Biol. Interact., 171, 108-116.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
2-(dimethylamino)ethyl (2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
 Homo sapiens
2-(dimethylamino)ethyl (2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoate
-
 Homo sapiens
2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine inhibition potencies, overview Homo sapiens
2-[[(2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
2-[[(2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium i.e. compound IIIf, a choline ester of dehydrophenylalanine, the amine group of the amino acid is derivatized with a benzoyl group containing a methoxy in the 2-position, binding structure and modelling, overview Homo sapiens
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
2-[[(2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
2-[[(2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
2-[[(2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
 Homo sapiens
iodine methylated 2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine inhibition potencies, overview Homo sapiens
N,N,N-trimethyl-2-([(2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoyl]oxy)ethanaminium iodide
-
 Homo sapiens
rivastigmine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P06276
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O detection using 5,5'-dithiobis(2-nitrobenzoic acid) Homo sapiens acetate + thiocholine
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium
0.00015
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0006
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
0.0009
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0011
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
0.0013
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0017
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0025
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
0.0028
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoate
0.0031
-
 pH 7.6, 25°C Homo sapiens N,N,N-trimethyl-2-([(2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoyl]oxy)ethanaminium iodide
0.00414
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoate
0.0138
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
0.0146
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0327
-
 pH 7.6, 25°C Homo sapiens 2-[[(2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
0.0402
-
 pH 7.6, 25°C Homo sapiens 2-(dimethylamino)ethyl (2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate