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Literature summary for 3.1.1.8 extracted from
- Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus (2006), Toxicology, 222, 185-194.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| azinphos-methyl | formation of the oxon derivative by the enzyme | Biomphalaria glabrata |  |
| azinphos-methyl | formation of the oxon derivative by the enzyme | Lumbriculus variegatus | |
| eserine | i.e. physostigmine, as hemisulfate salt, 82% inhibition at 1 mM, 72% at 0.05 mM | Biomphalaria glabrata | |
| eserine | i.e. physostigmine, as hemisulfate salt, 94% inhibition at 0.001 mM, 88% at 0.01 mM | Lumbriculus variegatus | |
| iso-ompa | i.e. tetraisopropyl diphosphoramide, inhibits the butyrylthiocholine esterase activity | Biomphalaria glabrata | |
| iso-ompa | i.e. tetraisopropyl diphosphoramide, inhibits the butyrylthiocholine esterase activity | Lumbriculus variegatus | |
| additional information | inhibition of ChE is not lethal | Biomphalaria glabrata | |
| additional information | inhibition of ChE is not lethal | Lumbriculus variegatus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | Biomphalaria glabrata | - |
thiocholine + acetate | - |
? | |
| acetylthiocholine + H2O | Lumbriculus variegatus | - |
thiocholine + acetate | - |
? | |
| butyrylthiocholine + H2O | Biomphalaria glabrata | - |
thiocholine + butyrate | - |
? | |
| butyrylthiocholine + H2O | Lumbriculus variegatus | - |
thiocholine + butyrate | - |
? | |
| additional information | Biomphalaria glabrata | inhibition of ChE is not lethal | ? | - |
? | |
| additional information | Lumbriculus variegatus | inhibition of ChE is not lethal | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Biomphalaria glabrata | - |
- |
- |
| Lumbriculus variegatus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Biomphalaria glabrata | thiocholine + acetate | - |
? | |
| acetylthiocholine + H2O | - |
Lumbriculus variegatus | thiocholine + acetate | - |
? | |
| acetylthiocholine + H2O | preferred substrate | Biomphalaria glabrata | thiocholine + acetate | - |
? | |
| butyrylthiocholine + H2O | - |
Biomphalaria glabrata | thiocholine + butyrate | - |
? | |
| butyrylthiocholine + H2O | - |
Lumbriculus variegatus | thiocholine + butyrate | - |
? | |
| butyrylthiocholine + H2O | preferred substrate | Lumbriculus variegatus | thiocholine + butyrate | - |
? | |
| additional information | inhibition of ChE is not lethal | Biomphalaria glabrata | ? | - |
? | |
| additional information | inhibition of ChE is not lethal | Lumbriculus variegatus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ChE | - |
Biomphalaria glabrata |
| ChE | - |
Lumbriculus variegatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Biomphalaria glabrata |
| 22 | - |
assay at | Lumbriculus variegatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Biomphalaria glabrata |
| 8 | - |
assay at | Lumbriculus variegatus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
- |
Biomphalaria glabrata | additional information | |
| additional information | - |
- |
Lumbriculus variegatus | additional information |
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