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Literature summary for 3.1.1.8 extracted from

  • Groner, E.; Ashani, Y.; Schorer-Apelbaum, D.; Sterling, J.; Herzig, Y.; Weinstock, M.
    The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates (2007), Mol. Pharmacol., 71, 1610-1617.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-methyl, N-alkyl carbamates inhibition of human BChE by divers derivatives of phenylethylamines and aminoindans is less influenced by the size of the alkyl group and more dependent on the structure of the leaving group, overview Homo sapiens
rivastigmine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetics, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
butyrylthiocholine + H2O Homo sapiens the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview thiocholine + butyrate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview Homo sapiens thiocholine + butyrate
-
?
butyrylthiocholine + H2O substrate as butyrylthiocholine iodide Homo sapiens thiocholine + butyrate
-
?

Synonyms

Synonyms Comment Organism
BChE
-
Homo sapiens
butyrylcholinesterase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, overview Homo sapiens