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Literature summary for 3.1.1.8 extracted from

  • Kovarik, Z.; Ciban, N.; Radic, Z.; Simeon-Rudolf, V.; Taylor, P.
    Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP (2006), Biochem. Biophys. Res. Commun., 342, 973-978.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
2,2-dichlorovinyl dimethyl phosphate i.e. DDVP, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7 Mus musculus
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride i.e. 2-PAM, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7 Mus musculus
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride i.e. HI-6, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 recombinant enzyme
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.027
-
 4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride pH 7.0, 25°C Mus musculus
0.34
-
 2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride pH 7.0, 25°C Mus musculus