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Literature summary for 3.1.1.8 extracted from
- Partial purification and characterization of soluble isoform of butyrylcholinesterase from rat intestine (2004), Protein J., 23, 143-151.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzoylthiocholine | substrate inhibition | Rattus norvegicus |  |
| Triton X-100 | inhibition above 0.01 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.047 | - |
Benzoylcholine | pH 7.4, 37°C | Rattus norvegicus | |
| 0.06 | - |
acetylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
| 0.087 | - |
acetylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
| 0.115 | - |
propionylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 260fold | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4612 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine | Rattus norvegicus | thiocholine + acetate | - |
? | |
| benzoylcholine + H2O | - |
Rattus norvegicus | choline + benzoate | - |
? | |
| butyrylthiocholine + H2O | increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine | Rattus norvegicus | thiocholine + butyrate | - |
? | |
| propionylthiocholine + H2O | increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine | Rattus norvegicus | thiocholine + propionate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | nonreducing PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Rattus norvegicus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | - |
acetylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
| 16.8 | - |
Benzoylcholine | pH 7.4, 37°C | Rattus norvegicus | |
| 23.5 | - |
acetylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
| 49.2 | - |
propionylthiocholine | pH 7.4, 37°C | Rattus norvegicus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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