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Literature summary for 3.1.1.8 extracted from
- Cholinesterases: New roles in brain function and in Alzheimer's disease (2003), Neurochem. Res., 28, 515-522.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bambuterol | inhibition in the nanomolar range | Homo sapiens |  |
| bisnorcymserine | inhibition in the nanomolar range | Homo sapiens | |
| cymserine | inhibition in the nanomolar range | Homo sapiens | |
| donepezil | 50% inhibition at 0.004 mM | Homo sapiens | |
| eptastigmine | inhibition in the nanomolar range | Homo sapiens | |
| ethopropazine | inhibition in the nanomolar range | Homo sapiens | |
| galantamine | 50% inhibition at 0.0073 mM | Homo sapiens | |
| huperzine | 50% inhibition at 0.03 mM | Homo sapiens | |
| iso-ompa | inhibition in the nanomolar range | Homo sapiens | |
| metrifonate | 50% inhibition at 0.018 mM | Homo sapiens | |
| phenserine | 50% inhibition at 0.0015 mM | Homo sapiens | |
| phenylethylcymserine | inhibition in the nanomolar range | Homo sapiens | |
| physostigmine | inhibition in the nanomolar range | Homo sapiens | |
| rivastigmine | 50% inhibition at 0.054 mM | Homo sapiens | |
| tacrine | inhibition in the nanomolar range | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| glial cell | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
| butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? | |
| additional information | butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| butyrocholinesterase | - |
Homo sapiens |
| ChE-II | - |
Homo sapiens |
| serum cholinesterase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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