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Literature summary for 3.1.1.8 extracted from

  • Zhan, C.G.; Zheng, F.; Landry, D.W.
    Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase (2003), J. Am. Chem. Soc., 125, 2462-2474.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(+)-cocaine
-
 Homo sapiens
(-)-cocaine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
an acylcholine + H2O = choline + a carboxylate mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cocaine + H2O
-
 Homo sapiens ?
-
 ?
(-)-cocaine + H2O is hydrolyzed less well than (+)-cocaine Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0085
-
 (+)-cocaine pH 7.4, 25°C Homo sapiens
0.009
-
 (-)-cocaine pH 7.4, 37°C Homo sapiens