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Literature summary for 3.1.1.7 extracted from

  • Herkert, N.M.; Freude, G.; Kunz, U.; Thiermann, H.; Worek, F.
    Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase (2012), Toxicol. Lett., 209, 173-178.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Cavia porcellus
HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Homo sapiens
HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Sus scrofa
obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Cavia porcellus
obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Homo sapiens
obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
paraoxon more than 95% inhibition at 0.001 mM Cavia porcellus
paraoxon more than 95% inhibition at 0.001 mM Homo sapiens
paraoxon more than 95% inhibition at 0.001 mM Sus scrofa
sarin more than 95% inhibition at 50 nM Cavia porcellus
sarin more than 95% inhibition at 30 nM Homo sapiens
sarin more than 95% inhibition at 50 nM Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0923
-
acetylthiocholine enzyme from erythrocyte, pH and temperature not specified in the publication Homo sapiens
0.0924
-
acetylthiocholine enzyme from muscle, pH and temperature not specified in the publication Homo sapiens
0.1011
-
acetylthiocholine enzyme from brain, pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Cavia porcellus
-
choline + acetate
-
?
acetylcholine + H2O Homo sapiens
-
choline + acetate
-
?
acetylcholine + H2O Sus scrofa
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Cavia porcellus
-
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
erythrocyte
-
Cavia porcellus
-
erythrocyte
-
Homo sapiens
-
erythrocyte
-
Sus scrofa
-
muscle
-
Cavia porcellus
-
muscle
-
Homo sapiens
-
muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Cavia porcellus choline + acetate
-
?
acetylcholine + H2O
-
Homo sapiens choline + acetate
-
?
acetylcholine + H2O
-
Sus scrofa choline + acetate
-
?
acetylthiocholine + H2O
-
Cavia porcellus thiocholine + acetate
-
?
acetylthiocholine + H2O
-
Homo sapiens thiocholine + acetate
-
?
acetylthiocholine + H2O
-
Sus scrofa thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Cavia porcellus
AChE
-
Homo sapiens
AChE
-
Sus scrofa