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Literature summary for 3.1.1.7 extracted from

  • Sukhorukov, A.Y.; Nirvanappa, A.C.; Swamy, J.; Ioffe, S.L.; Nanjunda Swamy, S.; Basappa, S.; Rangappa, K.S.
    Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase (2014), Bioorg. Med. Chem. Lett., 24, 3618-3621.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
-
 Homo sapiens
2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione
-
 Homo sapiens
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
-
 Homo sapiens
dimethyl [(10R)-10-(4-methoxyphenyl)-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]propanedioate
-
 Homo sapiens
dimethyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]propanedioate
-
 Homo sapiens
dimethyl [(4R)-4,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate
-
 Homo sapiens
dimethyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate
-
 Homo sapiens
dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate
-
 Homo sapiens
dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate
-
 Homo sapiens
methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate
-
 Homo sapiens
methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate
-
 Homo sapiens
methyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]acetate
-
 Homo sapiens
neostigmine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0024
-
 pH and temperature not specified in the publication Homo sapiens neostigmine
0.0025
-
 pH and temperature not specified in the publication Homo sapiens 2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
0.0063
-
 pH and temperature not specified in the publication Homo sapiens methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate
0.012
-
 pH and temperature not specified in the publication Homo sapiens dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
0.01435
-
 pH and temperature not specified in the publication Homo sapiens dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
0.03512
-
 pH and temperature not specified in the publication Homo sapiens methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate
0.04676
-
 pH and temperature not specified in the publication Homo sapiens dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate
0.06532
-
 pH and temperature not specified in the publication Homo sapiens 2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione
0.07535
-
 pH and temperature not specified in the publication Homo sapiens dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate