Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition and blockade of muscarinic receptors by serpentine precursor ajmaline at 0.08 mM, weak by catharanthine at over 0.01 mM, but both compounds inhibit nicotinic receptors in a reversible but non-competitive manner, a more potent nicotinic antagonist is tubocurarine | Rattus norvegicus | |
physostigmine | - |
Electrophorus electricus | |
physostigmine | - |
Rattus norvegicus | |
serpentine | isolated from aqueous extracts of Catharanthus roseus roots | Electrophorus electricus | |
serpentine | isolated from aqueous extracts of Catharanthus roseus roots, competitive blockade of muscarinic receptors with high efficiency | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | Rattus norvegicus | - |
acetate + thiocholine | - |
? | |
acetylthiocholine + H2O | Electrophorus electricus | - |
acetate + thiocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | - |
- |
- |
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Electrophorus electricus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Rattus norvegicus | acetate + thiocholine | - |
? | |
acetylthiocholine + H2O | - |
Electrophorus electricus | acetate + thiocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Rattus norvegicus |
AChE | - |
Electrophorus electricus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Electrophorus electricus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000775 | - |
- |
Electrophorus electricus | serpentine | |
0.00645 | - |
- |
Electrophorus electricus | physostigmine |