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Literature summary for 3.1.1.7 extracted from

  • Halldorsdottir, E.S.; Jaroszewski, J.W.; Olafsdottir, E.S.
    Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre (2010), Phytochemistry, 71, 149-157.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acrifoline isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
anhydrolycodoline isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
annotine isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
annotine N-oxide isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
annotinine isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
gnidioidine isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
lannotinidine D isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
lycodoline isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
lycofoline isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
lycoposerramine M isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre Electrophorus electricus
additional information isolation of acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre, NMR structure determination, and molecular modelling of interactions of the alkaloids with the enzyme, overview Electrophorus electricus
physostigmine
-
Electrophorus electricus

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Electrophorus electricus
-

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00084
-
-
Electrophorus electricus physostigmine
0.191
-
-
Electrophorus electricus anhydrolycodoline
0.404
-
-
Electrophorus electricus annotine N-oxide
0.6
-
-
Electrophorus electricus lycofoline
0.86
-
-
Electrophorus electricus annotine
1.625
-
-
Electrophorus electricus acrifoline
1.72
-
-
Electrophorus electricus gnidioidine
2
-
above Electrophorus electricus annotinine
2
-
above Electrophorus electricus lycodoline
2
-
above Electrophorus electricus lycoposerramine M