Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | acute toxicity of the nerve agents in guinea pigs is age- and sex-dependent and cannot be fully accounted for by the irreversible inhibition of AChE | Cavia porcellus | |
O-isopropyl methylphosphonofluoridate | i.e. sarin, a nerve agent, leads to irrversible inhibition of AChE | Cavia porcellus | |
O-pinacolyl methylphosphonofluoridate | i.e. soman, a nerve agent, leads to irrversible inhibition of AChE | Cavia porcellus | |
S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate | i.e. VX, a nerve agent, leads to irrversible inhibition of AChE | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
male and female Hartley guinea pigs | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Cavia porcellus | - |
blood plasma | - |
Cavia porcellus | - |
brain | - |
Cavia porcellus | - |
erythrocyte | - |
Cavia porcellus | - |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Cavia porcellus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cavia porcellus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Cavia porcellus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000029 | - |
pH 7.4, 37°C | Cavia porcellus | O-pinacolyl methylphosphonofluoridate | |
0.00000338 | - |
pH 7.4, 37°C | Cavia porcellus | S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate | |
0.00000727 | - |
pH 7.4, 37°C | Cavia porcellus | O-isopropyl methylphosphonofluoridate |