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Literature summary for 3.1.1.7 extracted from

  • Fawcett, W.P.; Aracava, Y.; Adler, M.; Pereira, E.F.; Albuquerque, E.X.
    Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition (2009), J. Pharmacol. Exp. Ther., 328, 516-524.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information acute toxicity of the nerve agents in guinea pigs is age- and sex-dependent and cannot be fully accounted for by the irreversible inhibition of AChE Cavia porcellus
O-isopropyl methylphosphonofluoridate i.e. sarin, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus
O-pinacolyl methylphosphonofluoridate i.e. soman, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus
S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate i.e. VX, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
male and female Hartley guinea pigs
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Cavia porcellus
-
blood plasma
-
Cavia porcellus
-
brain
-
Cavia porcellus
-
erythrocyte
-
Cavia porcellus
-

Synonyms

Synonyms Comment Organism
AChE
-
Cavia porcellus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cavia porcellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Cavia porcellus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000029
-
pH 7.4, 37°C Cavia porcellus O-pinacolyl methylphosphonofluoridate
0.00000338
-
pH 7.4, 37°C Cavia porcellus S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate
0.00000727
-
pH 7.4, 37°C Cavia porcellus O-isopropyl methylphosphonofluoridate