Protein Variants | Comment | Organism |
---|---|---|
additional information | donepezil accelerates angiogenesis even in alpha7 KO mice with hindlimb ischemia. alpha7 KO mice phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
donepezil | besides inhibiting the acetylcholinesterase donepezil can act as a therapeutic tool to accelerate angiogenesis in cardiovascular disease patients, overview | Homo sapiens | |
donepezil | donepezil concomitantly elevates VEGF expression in intracardiac endothelial cells of wild-type and alpha7 KO mice and further increases choline acetyltransferase protein expression, which is critical for acetylcholine synthesis in endothelial cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Mus musculus | acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion | acetate + choline | - |
? | |
acetylcholine + H2O | Homo sapiens | acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion | acetate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male C57BL6/J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical vein endothelial cell | HUVECs | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Mus musculus | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Homo sapiens | acetate + choline | - |
? | |
acetylcholine + H2O | acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion | Mus musculus | acetate + choline | - |
? | |
acetylcholine + H2O | acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion | Homo sapiens | acetate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Mus musculus |
AChE | - |
Homo sapiens |