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Literature summary for 3.1.1.7 extracted from

  • Dohi, S.; Terasaki, M.; Makino, M.
    Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils (2009), J. Agric. Food Chem., 57, 4313-4318.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,8-cineole IC50 is 0.015 mg/ml Electrophorus electricus
alpha-pinene IC50 is 0.022 mg/ml Electrophorus electricus
alpha-terpineol IC50 is 1.3 mg/ml Electrophorus electricus
eugenol IC50 is 0.48 mg/ml Electrophorus electricus
additional information commercially available essential oils extracted from Artemisia dracunculus L., Inula graveolens L., Lavandula officinalis Chaix, and Ocimum sanctum L. show inhibitory activity on the enzyme, with highest inhibitory activity of Artemisia dracunculus oil with an IC50 of 0.058 mg/ml, overview Electrophorus electricus
terpinen-4-ol IC50 is 3.2 mg/ml Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
acetate + choline
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus acetate + choline
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pH not specified in the publication Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50s: for 1,8-cineole 0.015 mg/ml, for alpha-pinene 0.022 mg/ml, for eugenol 0.48 mg/ml, for alpha-terpineol 1.3 mg/ml, for terpinen-4-ol 3.2 mg/ml, at 37°C, pH not specified in the publication Electrophorus electricus additional information